A Method for Degenerate Primer Design Based on Artificial Bee Colony Algorithm
نویسندگان
چکیده
Aiming to address the complex degenerate primer design problem in biological field, this paper, we a optimization model considering coverage and degeneracy that allows small number of base mismatches, propose global method based on artificial bee colony algorithm. The proposed algorithm combines idea ant with process algorithm, overcomes disadvantage uncertain candidate solution length solving discrete problems, designs search space according construction redesigns various foraging strategies information. In comparative experiments DNA template sequences different scales, designed by is superior existing methods terms stability, specificity, degeneracy.
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ژورنال
عنوان ژورنال: Applied sciences
سال: 2022
ISSN: ['2076-3417']
DOI: https://doi.org/10.3390/app12104992